Silica- bound benzoyl chloride mediated the solid- phase synthesis of 4H-3,1-benzoxazin- 4-ones

• Kurosh Rad-Moghadam and
• Somayeh Rouhi

Beilstein J. Org. Chem. 2009, 5, No. 13, doi:10.3762/bjoc.5.13

• Kurosh Rad-Moghadam Somayeh Rouhi Chemistry Department, University of Guilan, P.O. Box 41335-19141, Rasht, Iran 10.3762/bjoc.5.13 Abstract The solid-phase synthesis of 4H-3,1-benzoxazin-4-ones was achieved using silica-bound benzoyl chloride (SBBC) as dehydrating agent in reaction with 2

• -acylaminobenzoic acids. The silica-grafted reagent (SBBC) was simply recovered after reaction and reused several times. Keywords: 4H-3,1-benzoxazin-4-one; silica-bound benzoyl chloride; solid-phase synthesis; Introduction Solid-phase approaches are gaining more and more applications in organic synthesis mainly

• agents like acetic anhydride or sulfuric acid usually suffers from difficulties encountered in their handling, separation, and recovery after the reaction and may lead to environmental pollution. To eliminate these disadvantages we intended to evaluate the silica-bound benzoyl chloride (SBBC) as a solid